The Louisville Cardinals have finalized their opponents for the 2025-2026 college basketball season.
Their season opener is scheduled for November 12 at the KFC Yum! Center, where they will host the Colorado Buffaloes.
The Cardinals will conclude their regular season on February 15 at home against the Florida State Seminoles, also at the KFC Yum! Center.
During the regular season, Louisville will compete in 15 games, with 13 held at home and two played either away or at neutral venues.
Some games may change due to unforeseen mid-season circumstances.
| Date | Time | Opponent | Venue |
|---|---|---|---|
| Nov. 12 | 7 p.m. | Colorado Buffaloes | KFC Yum! Center |
| Nov. 19 | 8 p.m. | Morehead State Eagles | KFC Yum! Center |
| Nov. 22 | 2 p.m. | Kentucky Wildcats | KFC Yum! Center |
| Nov. 28 | 7 p.m. | Eastern Illinois Panthers | KFC Yum! Center |
| Nov. 30 | 2 p.m. | Bellarmine Knights | KFC Yum! Center |
| Dec. 7 | 12 p.m. | New Hampshire Wildcats | KFC Yum! Center |
| Dec. 10 | 9 p.m. | Ball State Cardinals | KFC Yum! Center |
| Dec. 17 | 6 p.m. | Eastern Kentucky Colonels | KFC Yum! Center |
| Jan. 1 | 2 p.m. | SMU Mustangs | KFC Yum! Center |
| Jan. 18 | 1 p.m. | North Carolina State Wolfpack | William Neal Reynolds Coliseum |
| Jan. 25 | 2 p.m. | Boston Eagles | KFC Yum! Center |
| Feb. 1 | 2 p.m. | California Golden Bears | Haas Pavilion |
| Feb. 5 | 7 p.m. | Duke Blue Devils | KFC Yum! Center |
| Feb. 12 | 7 p.m. | Wake Forest Deacons | KFC Yum! Center |
| Feb. 15 | 6 p.m. | Florida State Seminoles | KFC Yum! Center |



